Which will be the champion? Polydatin,Trans-Resveratrol or Pterostilbene?

The rise of many herbal extracts is inspired by international demand. Therefore, the markets of these products fluctuate up and down with the international demand changes. Resveratrol is one of them, while Polydatin is not. Polydatin is a specific ingredient intensively researched based on Chinese Traditional Medical theories in China,

 

 

Since 1970s and 1980s, Chinese scientists have begun to research Polydatin. According to Mr.Liu, General Manager of Shaanxi Yongyuan Bio-Tech Co.,Ltd., the Second Military Medical University and other new medicines research centers are in the process of 3rd clinical trials for Polydatin. However, R&D of medicine is a long period, and the future is uncertain. So, at present, Polydatin is still a nonmainstream product both on domestic and international markets. Lacking the support of international scientific research, it is really hard for Polydatin developing on international market .As we know, Polydatin has begun to export in small quantity since ten years ago, but until now, there is no marked increase in export.

 

 

Mr. Liu said, Polydatin is a single active ingredient, directly extracted from Huzhang. The international market generally demands 98%+ Polydatin while 90% Polydatin on domestic market. Hydrolyzing aglucones of Polydatin, we will get Resveratrol. It is to say, Polydatin is the precursor of Resveratrol. In Mr. Liu’s opinion, there is some joyful news this year. Besides the exploitation domestic market, we also exported Polydatin to foreign market, which is our first export of Polydatin since we launched it in 2002.

When Resveratrol rose to fame, Polydatin didn’t. On the contrary, the hot of Resveratrol brought high pressure to the poor market of Polydatin .As it is known to the earliest professionals of Resveratrol, in fact, the development of Resveratrol is young compared with Polydatin .It is just because of the demand pull on international market, that it becomes hot. In the earliest, when Harvard researchers declared the shocking information—Resveratrol can activate human longevity genes, what they used in research is Resveratrol extracted from grape peels. Following it, many research centers began to be keen on Resveratrol and the Resveratrol supplements were expecting to develop .As the low content of Resveratrol in grape peels, the production cost is very high. Therefore, Polydatin was exploited to be the substitute of Resveratrol. The whole world is familiar with Resveratrol, and some may know Huzhang, but a few people know Polydatin.

 

In fact, the hydrolysis of Polydatin is better than Resveratrol and it has stronger effects on metabolism and hereditation as reported. According to herbrideg.com, the international market demands higher level on Resveratrol’s hydrolysis, Millirod dosage form and other performances, in order to improve its usability rate. It is quite possible that, Polydatin will attract more attention from international research centers.

 

 

It is reported that Biltivia launched a new supplement—PteroMax, which contains Pterostilbene, trans-Resveratrol and Polydatin. Pterostilbene is a new ingredient, extracted from blueberry and other fruit. Pterostilbene is the homologs of Resveratrol, and with stronger effects on reducing cholesterol, improving cognitive function than Resveratrol. Some scientific research also indicates that there is enhanced effect when using Pterostilbene, Polydatin and Resveratrol together. It may be an opportunity for Polydatin and Pterostilbene to enter the big supplement market.

 

As reported, there are some research reports about Polydatin in China. For example:

 Polydatin adjust Calcium level and membrane potential in normal human’s VSMC; Polydatin affects the adhesion of white blood cells and endothelial cells

Polydatin prevents and cures endotoxic Cardiomyocytes Injury;Polydatin affects lipopolysaccharide ‘s induction on VEC  ICAM-1;Polydatin affects the neutrophils’s chemotaxis reaction inspired by lipopolysaccharide;Polydatin affects smooth muscle and Cardiomyocytes PKC under the situation of ischemia, hypoxia, burn serum, and LPS;Polydatin was used in treating severe Acute Pancreatitis in the early stage;Polydatin affects TLR4 when reducing the injury occurred during perfusing blood to ischemic Rabbit lung;Experiments and researches both in vitro and in vivo on of Polydatin curing Viral Myocarditis.

 

And other research reports.

 

 

This September, ChromaDex listed Pterostilbene as its focus developing product. ChromaDex researches Pterostilbene in clinical trials in order to confirm its effect on people with Lipid Disorders. At the same time, ChromaDex has already sold Pterostilbene derived from herbs in United States. It is seen to be a promising ingredient in this industry, which will possibly promote Resveratrol rise from the low market, and promote Polydatin known to the world.

 

Huzhang is usually collected from December to next May .At present, even though Resveratrol demand is in continuing downturn, and the common prices rise in raw materials for herbal extracts, the price of Polydatin keeps more or less the same. Shaanxi Yongyuan Bio-Tech. Co.,Ltd. will attach further investment on R&D of Polydatin, Trans-Resveratrol and Pterostilbene ,and go on promoting such products.

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